ncRNA name | ASPP2 siRNA |
ncRNA Category | siRNA |
Disease name | proliferative vitreoretinopathy (PVR) |
Species | Homo sapiens |
Tissues/Cell_line | human RPE cell line ARPE-19 |
Methods | siRNA transfection, qRT-PCR, Western blot, immunocytochemistry |
Expression pattern | associated |
Functional description | ASPP2-siRNA increased EMT-related and inflammatory cytokines, including TGF-β, CTGF, VEGF, TNF-α, and interleukins. PVR severities were more pronounced in the rat models with ASPP2-siRNA treatment. |
PubMed ID | 27378826 |
Year | 2016 |
Title | Small Interfering RNA Targeted to ASPP2 Promotes Progression of Experimental Proliferative Vitreoretinopathy. |
Drug-related ncRNA | NO |
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